Novel Nanomolar Allosteric Modulators of AMPA Receptor of Bis(pyrimidine) Series: Synthesis, Biotesting and SAR Analysis

Positive allosteric modulators (PAMs) of AMPA receptors represent attractive candidates for the development of drugs for the treatment of cognitive and neurodegenerative disorders. Dimeric molecules have been reported to have an especially potent modulating effect, due to the U-shaped form of the AM...

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Detalles Bibliográficos
Autores principales: Sedenkova, Kseniya N., Zverev, Denis V., Nazarova, Anna A., Lavrov, Mstislav I., Radchenko, Eugene V., Grishin, Yuri K., Gabrel’yan, Alexey V., Zamoyski, Vladimir L., Grigoriev, Vladimir V., Averina, Elena B., Palyulin, Vladimir A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741252/
https://www.ncbi.nlm.nih.gov/pubmed/36500341
http://dx.doi.org/10.3390/molecules27238252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741252/
https://www.ncbi.nlm.nih.gov/pubmed/36500341
http://dx.doi.org/10.3390/molecules27238252

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