Micro-RNAs Shuttled by Extracellular Vesicles Secreted from Mesenchymal Stem Cells Dampen Astrocyte Pathological Activation and Support Neuroprotection in In-Vitro Models of ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no effective cure. Astrocytes display a toxic phenotype in ALS and contribute to motoneuron (MN) degeneration. Modulating astrocytes’ neurotoxicity can reduce MN death. Our previous studies showed the beneficial effect of mesenc...

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Detalles Bibliográficos
Autores principales: Provenzano, Francesca, Nyberg, Sophie, Giunti, Debora, Torazza, Carola, Parodi, Benedetta, Bonifacino, Tiziana, Usai, Cesare, Kerlero de Rosbo, Nicole, Milanese, Marco, Uccelli, Antonio, Shaw, Pamela J., Ferraiuolo, Laura, Bonanno, Giambattista
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741322/
https://www.ncbi.nlm.nih.gov/pubmed/36497181
http://dx.doi.org/10.3390/cells11233923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741322/
https://www.ncbi.nlm.nih.gov/pubmed/36497181
http://dx.doi.org/10.3390/cells11233923

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