FOXO3a Mediates Homologous Recombination Repair (HRR) via Transcriptional Activation of MRE11, BRCA1, BRIP1, and RAD50

To test whether homologous recombination repair (HRR) depends on FOXO3a, a cellular aging model of human dermal fibroblast (HDF) and tet-on flag-h-FOXO3a transgenic mice were studied. HDF cells transfected with over-expression of wt-h-FOXO3a increased the protein levels of MRE11, BRCA1, BRIP1, and R...

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Detalles Bibliográficos
Autores principales: Inci, Gozde, Warkad, Madhuri Shende, Kang, Beom-Goo, Lee, Na-Kyung, Suh, Hong-Won, Lim, Soon Sung, Kim, Jaebong, Kim, Sung-Chan, Lee, Jae-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741359/
https://www.ncbi.nlm.nih.gov/pubmed/36500714
http://dx.doi.org/10.3390/molecules27238623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741359/
https://www.ncbi.nlm.nih.gov/pubmed/36500714
http://dx.doi.org/10.3390/molecules27238623

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