Cargando…

FOXO3a Mediates Homologous Recombination Repair (HRR) via Transcriptional Activation of MRE11, BRCA1, BRIP1, and RAD50

To test whether homologous recombination repair (HRR) depends on FOXO3a, a cellular aging model of human dermal fibroblast (HDF) and tet-on flag-h-FOXO3a transgenic mice were studied. HDF cells transfected with over-expression of wt-h-FOXO3a increased the protein levels of MRE11, BRCA1, BRIP1, and R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Inci, Gozde, Warkad, Madhuri Shende, Kang, Beom-Goo, Lee, Na-Kyung, Suh, Hong-Won, Lim, Soon Sung, Kim, Jaebong, Kim, Sung-Chan, Lee, Jae-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741359/ https://www.ncbi.nlm.nih.gov/pubmed/36500714 http://dx.doi.org/10.3390/molecules27238623

Ejemplares similares

Purple corn extract (PCE) alleviates cigarette smoke (CS)-induced DNA damage in rodent blood cells by activation of AMPK/Foxo3a/MnSOD pathway
por: Kim, Wan-Sik, et al.
Publicado: (2021)

BRCA1 interactors, RAD50 and BRIP1, as prognostic markers for triple-negative breast cancer severity
por: Katheeja, Muhseena N., et al.
Publicado: (2023)

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
por: Warkad, Madhuri Shende, et al.
Publicado: (2021)

Mutation status of RAD51C,PALB2 and BRIP1 in 100 Japanese familial breast cancer cases without BRCA1 and BRCA2 mutations
por: Sato, Katsutoshi, et al.
Publicado: (2017)

Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals
por: Kuusisto, Kirsi M, et al.
Publicado: (2011)

The Rad50 Coiled Coil Domain is indispensable for Mre11 complex functions
por: Hohl, Marcel, et al.
Publicado: (2011)

Mre11-Rad50 oligomerization promotes DNA double-strand break repair
por: Kissling, Vera M., et al.
Publicado: (2022)

Clinical importance of FANCD2, BRIP1, BRCA1, BRCA2 and FANCF expression in ovarian carcinomas
por: Moes-Sosnowska, Joanna, et al.
Publicado: (2019)

Loss of the BRCA1-Interacting Helicase BRIP1 Results in Abnormal Mammary Acinar Morphogenesis
por: Daino, Kazuhiro, et al.
Publicado: (2013)

Analysis of BRIP1 Variants among Korean Patients with BRCA1/2 Mutation-Negative High-Risk Breast Cancer
por: Kim, Haeyoung, et al.
Publicado: (2016)

Dynamic Properties of the DNA Damage Response Mre11/Rad50 Complex
por: Vertemara, Jacopo, et al.
Publicado: (2023)

MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal Cancer
por: Situ, Yiling, et al.
Publicado: (2019)

MRE11 and RAD50, but not NBS1, are essential for gene targeting in the moss Physcomitrella patens
por: Kamisugi, Yasuko, et al.
Publicado: (2012)

Functional Interaction Between BRCA1 and DNA Repair in Yeast May Uncover a Role of RAD50, RAD51, MRE11A, and MSH6 Somatic Variants in Cancer Development
por: Maresca, Luisa, et al.
Publicado: (2018)

S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex
por: Chen, Yu-Jie, et al.
Publicado: (2016)

Plasticity of the Mre11–Rad50–Xrs2–Sae2 nuclease ensemble in the processing of DNA-bound obstacles
por: Wang, Weibin, et al.
Publicado: (2017)

Germline variants in MRE11/RAD50/NBN complex genes in childhood leukemia
por: Mosor, Maria, et al.
Publicado: (2013)

Deubiquitinase USP2 stabilizes the MRE11–RAD50–NBS1 complex at DNA double-strand break sites by counteracting the ubiquitination of NBS1
por: Kim, Hyunsup, et al.
Publicado: (2022)

The ATP-bound conformation of the Mre11–Rad50 complex is essential for Tel1/ATM activation
por: Cassani, Corinne, et al.
Publicado: (2019)

A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex
por: Rahman, Samiur, et al.
Publicado: (2020)

Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers
por: Alblihy, Adel, et al.
Publicado: (2021)

Novel role of BRCA1 interacting C‐terminal helicase 1 (BRIP1) in breast tumour cell invasion
por: Rizeq, Balsam, et al.
Publicado: (2020)

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex
por: Möckel, Carolin, et al.
Publicado: (2012)

The Mre11-Rad50-Xrs2 Complex Is Required for Yeast DNA Postreplication Repair
por: Ball, Lindsay G., et al.
Publicado: (2014)

The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers
por: Ziółkowska-Suchanek, Iwona, et al.
Publicado: (2013)

A novel mode of nuclease action is revealed by the bacterial Mre11/Rad50 complex
por: Lim, Chew Theng, et al.
Publicado: (2015)

Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma
por: Schuetz, Johanna M, et al.
Publicado: (2009)

The role of the Mre11–Rad50–Nbs1 complex in double-strand break repair—facts and myths
por: Takeda, Shunichi, et al.
Publicado: (2016)

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment
por: Bian, Lei, et al.
Publicado: (2019)

Mutation Spectra of the MRN (MRE11, RAD50, NBS1/NBN) Break Sensor in Cancer Cells
por: McPherson, Matthew T., et al.
Publicado: (2020)

Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin
por: Spycher, Christoph, et al.
Publicado: (2008)

Mre11-Rad50–dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1
por: Limbo, Oliver, et al.
Publicado: (2018)

Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis
por: Ho, Vincent, et al.
Publicado: (2018)

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments
por: Kolinjivadi, Arun Mouli, et al.
Publicado: (2017)

Age of ovarian cancer diagnosis among BRIP1, RAD51C, and RAD51D mutation carriers identified through multi-gene panel testing
por: Cummings, Shelly, et al.
Publicado: (2021)

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex
por: Lee, Kyung Yong, et al.
Publicado: (2015)

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks
por: Lee, Joon, et al.
Publicado: (2013)

A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair
por: Steininger, Sylvia, et al.
Publicado: (2010)

Mre11–Rad50–Xrs2 and Sae2 promote 5’ strand resection of DNA double-strand breaks
por: Nicolette, Matthew L., et al.
Publicado: (2010)

Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
por: Jazayeri, Ali, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_n4svrvom242kcn0n8aglohrpvt