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Role of Monovalent Ions in the NKCC1 Inhibition Mechanism Revealed through Molecular Simulations
The secondary active Na-K-Cl cotransporter 1 (NKCC1) promotes electroneutral uptake of two chloride ions, one sodium ion and one potassium ion. NKCC1 regulates Cl(−) homeostasis, thus being implicated in transepithelial water transport and in neuronal excitability. Aberrant NKCC1 transport is linked...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741434/ https://www.ncbi.nlm.nih.gov/pubmed/36499764 http://dx.doi.org/10.3390/ijms232315439 |