SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction

Mitochondrial NAD(+)‐dependent protein deacetylase Sirtuin3 (SIRT3) has been proposed to mediate calorie restriction (CR)‐dependent metabolic regulation and lifespan extension. Here, we investigated the role of SIRT3 in CR‐mediated longevity, mitochondrial function, and aerobic fitness. We report th...

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Detalles Bibliográficos
Autores principales: Dhillon, Rashpal S., Qin, Yiming (Amy), van Ginkel, Paul R., Fu, Vivian X., Vann, James M., Lawton, Alexis J., Green, Cara L., Manchado‐Gobatto, Fúlvia B., Gobatto, Claudio A., Lamming, Dudley W., Prolla, Tomas A., Denu, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741511/
https://www.ncbi.nlm.nih.gov/pubmed/36199173
http://dx.doi.org/10.1111/acel.13721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741511/
https://www.ncbi.nlm.nih.gov/pubmed/36199173
http://dx.doi.org/10.1111/acel.13721

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