Turning antibodies off and on again using a covalently tethered blocking peptide

In their natural form, antibodies are always in an “on-state” and are capable of binding to their targets. This leads to undesirable interactions in a wide range of therapeutic, analytical, and synthetic applications. Modulating binding kinetics of antibodies to turn them from an “off-state” to an “...

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Detalles Bibliográficos
Autores principales: Brasino, Michael, Wagnell, Eli, Hamilton, Sean, Ranganathan, Srivathsan, Gomes, Michelle M., Branchaud, Bruce, Messmer, Bradley, Ibsen, Stuart D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741643/
https://www.ncbi.nlm.nih.gov/pubmed/36496512
http://dx.doi.org/10.1038/s42003-022-04094-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741643/
https://www.ncbi.nlm.nih.gov/pubmed/36496512
http://dx.doi.org/10.1038/s42003-022-04094-1

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