Bispecific antibodies—effects of point mutations on C(H)3-C(H)3 interface stability

A new format of therapeutic proteins is bispecific antibodies, in which two different heavy chains heterodimerize to obtain two different binding sites. Therefore, it is crucial to understand and optimize the third constant domain (C(H)3-C(H)3) interface to favor heterodimerization over homodimeriza...

Descripción completa

Detalles Bibliográficos
Autores principales: Pomarici, Nancy D, Fernández-Quintero, Monica L, Quoika, Patrick K, Waibl, Franz, Bujotzek, Alexander, Georges, Guy, Liedl, Klaus R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741699/
https://www.ncbi.nlm.nih.gov/pubmed/36468666
http://dx.doi.org/10.1093/protein/gzac012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741699/
https://www.ncbi.nlm.nih.gov/pubmed/36468666
http://dx.doi.org/10.1093/protein/gzac012

Ejemplares similares