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Bispecific antibodies—effects of point mutations on C(H)3-C(H)3 interface stability
A new format of therapeutic proteins is bispecific antibodies, in which two different heavy chains heterodimerize to obtain two different binding sites. Therefore, it is crucial to understand and optimize the third constant domain (C(H)3-C(H)3) interface to favor heterodimerization over homodimeriza...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741699/ https://www.ncbi.nlm.nih.gov/pubmed/36468666 http://dx.doi.org/10.1093/protein/gzac012 |