Resistance to Cefiderocol Involved Expression of PER-1 β-Lactamase and Downregulation of Iron Transporter System in Carbapenem-Resistant Acinetobacter baumannii

BACKGROUND: Cefiderocol (CFDC) is a promising antimicrobial agent against multidrug resistant Gram-negative bacteria. However, CFDC resistance has emerged in carbapenem-resistant Acinetobacter baumannii (CR-AB) but the underlying mechanisms remain unclear. METHODS: Whole-genome sequencing and transc...

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Detalles Bibliográficos
Autores principales: He, Yukun, Wang, Yifan, Ma, Xinqian, Zhao, Lili, Guan, Jie, Zhao, Jin, Yu, Wenyi, Li, Yanjun, Ni, Wentao, Gao, Zhancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741825/
https://www.ncbi.nlm.nih.gov/pubmed/36514799
http://dx.doi.org/10.2147/IDR.S392241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741825/
https://www.ncbi.nlm.nih.gov/pubmed/36514799
http://dx.doi.org/10.2147/IDR.S392241

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