SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine

Suppressor of cytokine signaling (SOCS) 2 is the critical negative regulator of growth hormone (GH) and prolactin signaling. Mice lacking SOCS2 display gigantism with increased body weight and length, and an enhanced response to GH treatment. Here, we characterized mice carrying a germ-line R96C mut...

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Detalles Bibliográficos
Autores principales: Li, Kunlun, Meza Guzman, Lizeth G., Whitehead, Lachlan, Leong, Evelyn, Kueh, Andrew, Alexander, Warren S., Kershaw, Nadia J., Babon, Jeffrey J., Doggett, Karen, Nicholson, Sandra E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Cell Cycle, Growth & Proliferation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742514/
https://www.ncbi.nlm.nih.gov/pubmed/36398696
http://dx.doi.org/10.1042/BSR20221683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742514/
https://www.ncbi.nlm.nih.gov/pubmed/36398696
http://dx.doi.org/10.1042/BSR20221683

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