AKR1B8 deficiency drives severe DSS-induced acute colitis through invasion of luminal bacteria and activation of innate immunity

BACKGROUND: Dysfunction of intestinal epithelial cells (IECs) promotes inflammatory bowel disease (IBD) and associated colorectal cancer (CRC). AKR1B8 deficiency impairs the IEC barrier function, leading to susceptibility to chronic colitis induced by dextran sulfate sodium (DSS), yet it remains unc...

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Detalles Bibliográficos
Autores principales: Deng, Qiulin, Yao, Yichen, Yang, Jing, Khoshaba, Ramina, Shen, Yi, Wang, Xin, Cao, Deliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742539/
https://www.ncbi.nlm.nih.gov/pubmed/36518763
http://dx.doi.org/10.3389/fimmu.2022.1042549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742539/
https://www.ncbi.nlm.nih.gov/pubmed/36518763
http://dx.doi.org/10.3389/fimmu.2022.1042549

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