Inhibition of glycogen synthase kinase-3-beta (GSK3β) blocks nucleocapsid phosphorylation and SARS-CoV-2 replication

GSK3β has been proposed to have an essential role in Coronaviridae infections. Screening of a targeted library of GSK3β inhibitors against both SARS-CoV-2 and HCoV-229E to identify broad-spectrum anti-Coronaviridae inhibitors resulted in the identification of a high proportion of active compounds wi...

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Detalles Bibliográficos
Autores principales: Shapira, Tirosh, Vimalanathan, Selvarani, Rens, Celine, Pichler, Virginia, Peña-Díaz, Sandra, Jordana, Grace, Rees, William, Winkler, Dirk F. H., Sarai, Iqbal, Steiner, Theodore, Jean, François, Pelech, Steven, Av-Gay, Yossef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742639/
https://www.ncbi.nlm.nih.gov/pubmed/36508083
http://dx.doi.org/10.1186/s43556-022-00111-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742639/
https://www.ncbi.nlm.nih.gov/pubmed/36508083
http://dx.doi.org/10.1186/s43556-022-00111-1

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