Cargando…

Inhibition of glycogen synthase kinase-3-beta (GSK3β) blocks nucleocapsid phosphorylation and SARS-CoV-2 replication

GSK3β has been proposed to have an essential role in Coronaviridae infections. Screening of a targeted library of GSK3β inhibitors against both SARS-CoV-2 and HCoV-229E to identify broad-spectrum anti-Coronaviridae inhibitors resulted in the identification of a high proportion of active compounds wi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shapira, Tirosh, Vimalanathan, Selvarani, Rens, Celine, Pichler, Virginia, Peña-Díaz, Sandra, Jordana, Grace, Rees, William, Winkler, Dirk F. H., Sarai, Iqbal, Steiner, Theodore, Jean, François, Pelech, Steven, Av-Gay, Yossef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Nature Singapore 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742639/ https://www.ncbi.nlm.nih.gov/pubmed/36508083 http://dx.doi.org/10.1186/s43556-022-00111-1

Ejemplares similares

High-Content Screening of Eukaryotic Kinase Inhibitors Identify CHK2 Inhibitor Activity Against Mycobacterium tuberculosis
por: Shapira, Tirosh, et al.
Publicado: (2020)

DMN-Tre Labeling for Detection and High-Content Screening of Compounds against Intracellular Mycobacteria
por: Sahile, Henok A., et al.
Publicado: (2020)

Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging
por: Pandey, Mukesh K., et al.
Publicado: (2016)

Gaseous nitric oxide reduces influenza infectivity in vitro
por: Regev-Shoshani, Gilly, et al.
Publicado: (2013)

Inhibition of Glycogen Synthase Kinase 3 (GSK3) Increases the Cytotoxicity of Enzastaurin
por: Rovedo, Mark, et al.
Publicado: (2011)

Regulation of Autophagy by the Glycogen Synthase Kinase-3 (GSK-3) Signaling Pathway
por: Pan, Hsuan-Yeh, et al.
Publicado: (2022)

Expression of Glycogen synthase kinase 3-β (GSK3-β) gene in azoospermic men
por: Nazarian, Hamid, et al.
Publicado: (2014)

Glycogen Synthase Kinase-3 (GSK-3) Regulation of Inhibitory Coreceptor Expression in T-cell Immunity
por: Issa, Mark E., et al.
Publicado: (2021)

In Silico Approaches to Developing Novel Glycogen Synthase Kinase 3β (GSK-3β)
por: Goyal, Shuchi, et al.
Publicado: (2023)

Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells
por: Taylor, Alison, et al.
Publicado: (2020)

From infection niche to therapeutic target: the intracellular lifestyle of Mycobacterium tuberculosis
por: Rankine-Wilson, Leah Isobella, et al.
Publicado: (2021)

Glycogen Synthase Kinase-3 Interaction Domain Enhances Phosphorylation of SARS-CoV-2 Nucleocapsid Protein
por: Yun, Jun Seop, et al.
Publicado: (2022)

Glycogen Synthase Kinase-3
por: Crouch, Peter, et al.
Publicado: (2011)

Glycogen Synthase Kinase 3 Beta (GSK3β) Phosphorylates the RNAase III Enzyme Drosha at S300 and S302
por: Tang, Xiaoli, et al.
Publicado: (2011)

Glycogen Synthase Kinase 3 (GSK3) Inhibitor, SB-216763, Promotes Pluripotency in Mouse Embryonic Stem Cells
por: Kirby, Leslie A., et al.
Publicado: (2012)

Glycogen Synthase Kinase-3 Regulates the Phosphorylation of Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein and Viral Replication
por: Wu, Chia-Hsin, et al.
Publicado: (2009)

Deletion of Macrophage-Specific Glycogen Synthase Kinase (GSK)-3α Promotes Atherosclerotic Regression in Ldlr(−/−) Mice
por: Patel, Sarvatit, et al.
Publicado: (2022)

Tissue-Specific Analysis of Glycogen Synthase Kinase-3α (GSK-3α) in Glucose Metabolism: Effect of Strain Variation
por: Patel, Satish, et al.
Publicado: (2011)

The role of activation of PERK in activating glycogen synthase kinase 3(GSK-3) by oleic acid(OA) in type 2 diabetes
por: Wu, Wei, et al.
Publicado: (2013)

Phosphorylated Glycogen Synthase Kinase-3β (GSK-3β) Improves Cognition in Rats with Diabetes-Associated Cognitive Decline
por: Ke, Boxi, et al.
Publicado: (2019)

Glycogen synthase kinase-3 beta (GSK3β)-mediated phosphorylation of ETS1 promotes progression of ovarian carcinoma
por: Tsai, Chia-Lung, et al.
Publicado: (2021)

The role of glycogen synthase kinase 3 (GSK3) in cancer with emphasis on ovarian cancer development and progression: A comprehensive review
por: Glibo, Mislav, et al.
Publicado: (2021)

Glycogen Synthase Kinase 3β (GSK3β) Regulates Myogenic Differentiation in Skeletal Muscle Satellite Cells of Sheep
por: Yang, Jingquan, et al.
Publicado: (2022)

Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition
por: Liu, Xiaolei, et al.
Publicado: (2021)

Functional inactivation of Plasmodium falciparum glycogen synthase kinase GSK3 modulates erythrocyte invasion and blocks gametocyte maturation
por: Alder, Arne, et al.
Publicado: (2022)

Alternative Splicing of the Porcine Glycogen Synthase Kinase 3β (GSK-3β) Gene with Differential Expression Patterns and Regulatory Functions
por: Wang, Linjie, et al.
Publicado: (2012)

Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3)
por: Logie, Lisa, et al.
Publicado: (2017)

Retracted: Phosphorylated Glycogen Synthase Kinase-3β (GSK-3β) Improves Cognition in Rats with Diabetes-Associated Cognitive Decline
por: Ke, Boxi, et al.
Publicado: (2019)

Interactomes of Glycogen Synthase Kinase-3 Isoforms
por: Cormier, Kevin W., et al.
Publicado: (2023)

Echinacea—A Source of Potent Antivirals for Respiratory Virus Infections
por: Hudson, James, et al.
Publicado: (2011)

Potential involvement of glycogen synthase kinase (GSK)-3β in a rat model of multiple sclerosis: evidenced by lithium treatment
por: Ahn, Meejung, et al.
Publicado: (2017)

Glycogen synthase kinase GSK3α promotes tumorigenesis by activating HIF1/VEGFA signaling pathway in NSCLC tumor
por: Cao, Xiaonian, et al.
Publicado: (2022)

Multiple Alternative Splicing and Differential Expression Pattern of the Glycogen Synthase Kinase-3β (GSK3β) Gene in Goat (Capra hircus)
por: Hou, Yuguo, et al.
Publicado: (2014)

The role of glycogen synthase kinase-3β (GSK-3β) in endometrial carcinoma: A carcinogenesis, progression, prognosis, and target therapy marker
por: Chen, Shuo, et al.
Publicado: (2016)

Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation
por: Amaral, Ana Claudia, et al.
Publicado: (2021)

The association of glycogen synthase kinase-3beta (GSK-3β) gene polymorphism with kidney function in long-term lithium-treated bipolar patients
por: Rybakowski, Janusz K, et al.
Publicado: (2013)

Glycogen synthase kinase-3 (Gsk-3) plays a fundamental role in maintaining DNA methylation at imprinted loci in mouse embryonic stem cells
por: Meredith, Gavin D., et al.
Publicado: (2015)

Deletion of Cardiomyocyte Glycogen Synthase Kinase-3 Beta (GSK-3β) Improves Systemic Glucose Tolerance with Maintained Heart Function in Established Obesity
por: Gupte, Manisha, et al.
Publicado: (2020)

Dysregulated levels of glycogen synthase kinase-3β (GSK-3β) and miR-135 in peripheral blood samples of cases with nephrotic syndrome
por: Ardalan, Mohammadreza, et al.
Publicado: (2020)

Glycogen synthase kinase 3β (GSK3β) and presenilin (PS) are key regulators of kinesin-1-mediated cargo motility within axons
por: Banerjee, Rupkatha, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3upmudbqieh3blffbga9n54ljs