Modulation of p-glycoprotein-mediated efflux pirarubicin in living multidrug-resistant K562/Dox cell lines by 4-hydroxybenzoic acid and 4-hydroxy-3-methoxybenzoic acid via impairment of the cellular energetic state

The objective was to investigate the effect of 4-hydroxybenzoic acid (4-HBA) and 4-hydroxy-3-methoxybenzoic acid (Vanillic acid, VA) on p-glycoprotein (P-gp) activity in multidrug-resistant K562/Dox cancer cells. The cytotoxic and co-treatment with pirarubicin (Pira) were analyzed using a resazurin...

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Detalles Bibliográficos
Autores principales: Myint, Ohnmar, Wattanapongpitak, Sakornniya, Kothan, Suchart, Udomtanakunchai, Chatchanok, Tima, Singkome, Tungjai, Montree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742882/
https://www.ncbi.nlm.nih.gov/pubmed/36518452
http://dx.doi.org/10.1016/j.toxrep.2022.06.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742882/
https://www.ncbi.nlm.nih.gov/pubmed/36518452
http://dx.doi.org/10.1016/j.toxrep.2022.06.017

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