Safety assessment of the fungal immunomodulatory protein from Ganoderma microsporum (GMI) derived from engineered Pichia pastoris: Genetic toxicology, a 13-week oral gavage toxicity study, and an embryo-fetal developmental toxicity study in Sprague-Dawley rats

The 12.4 kDa fungal immunomodulatory protein from Ganoderma microsporum (GMI) has bioactivity in vitro and in vivo. This study assessed the safety of GMI derived from engineered Pichia pastoris in Sprague-Dawley rats as a dietary supplement and food ingredient by evaluating subchronic toxicity, tera...

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Detalles Bibliográficos
Autores principales: Fu, Hsu-Yuan, Hseu, Ruey-Shyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742912/
https://www.ncbi.nlm.nih.gov/pubmed/36518484
http://dx.doi.org/10.1016/j.toxrep.2022.05.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742912/
https://www.ncbi.nlm.nih.gov/pubmed/36518484
http://dx.doi.org/10.1016/j.toxrep.2022.05.013

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