Aggregation-prone A53T mutant of α-synuclein exaggerates methamphetamine neurotoxicity in SH-SY5Y cells: Protective role of cellular cholesterol

The aim of this study is to examine the effects of wild type as well as a mutant (A53T) form of α-synuclein (α-syn) on neuronal cells exposed to methamphetamine (METH). SH-SY5Y human dopaminergic neuronal cells stably expressing exogenously added wild type (WT) or A53T α-syn were established for thi...

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Detalles Bibliográficos
Autores principales: Aoki, Sho, Funakoshi, Takeshi, Aki, Toshihiko, Uemura, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742969/
https://www.ncbi.nlm.nih.gov/pubmed/36518421
http://dx.doi.org/10.1016/j.toxrep.2022.11.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9742969/
https://www.ncbi.nlm.nih.gov/pubmed/36518421
http://dx.doi.org/10.1016/j.toxrep.2022.11.006

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