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Sex-dependent sensitivity to positive allosteric modulation of GABA action in an APP knock-in mouse model of Alzheimer's disease: Potential epigenetic regulation
Conflicting evidence suggest that perturbations of GABAergic neurotransmission play crucial roles in disrupting cortical neuronal network oscillations, memory, and cognitive deficits in Alzheimer's disease (AD). However, the role and impact of sex differences on GABAergic transmission in AD are...
Autores principales: | Auta, James, Locci, Andrea, Guidotti, Alessandro, Davis, John M., Dong, Hongxin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743067/ https://www.ncbi.nlm.nih.gov/pubmed/36518344 http://dx.doi.org/10.1016/j.crneur.2021.100025 |
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