Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor

[Image: see text] We synthesized new aroyl diheterocyclic pyrrole (ARDHEP) 15 that exhibited the hallmarks of ferroptosis. Compound 15 strongly inhibited U-87 MG, OVCAR-3, and MCF-7 cancer cells, induced an increase of cleaved PARP, but was not toxic for normal human primary T lymphocytes at 0.1 μM....

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Detalles Bibliográficos
Autores principales: Puxeddu, Michela, Wu, Jianchao, Bai, Ruoli, D’Ambrosio, Michele, Nalli, Marianna, Coluccia, Antonio, Manetto, Simone, Ciogli, Alessia, Masci, Domiziana, Urbani, Andrea, Fionda, Cinzia, Coni, Sonia, Bordone, Rosa, Canettieri, Gianluca, Bigogno, Chiara, Dondio, Giulio, Hamel, Ernest, Liu, Te, Silvestri, Romano, La Regina, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743090/
https://www.ncbi.nlm.nih.gov/pubmed/36395526
http://dx.doi.org/10.1021/acs.jmedchem.2c01457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743090/
https://www.ncbi.nlm.nih.gov/pubmed/36395526
http://dx.doi.org/10.1021/acs.jmedchem.2c01457

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