Membrane-Active Cyclic Amphiphilic Peptides: Broad-Spectrum Antibacterial Activity Alone and in Combination with Antibiotics

[Image: see text] We designed a library of 24 cyclic peptides containing arginine (R) and tryptophan (W) residues in a sequential manner [R(n)W(n)] (n = 2–7) to study the impact of the hydrophilic/hydrophobic ratio, charge, and ring size on the antibacterial activity against Gram-positive and Gram-n...

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Detalles Bibliográficos
Autores principales: Mohammed, Eman H. M., Lohan, Sandeep, Ghaffari, Tarra, Gupta, Shilpi, Tiwari, Rakesh K., Parang, Keykavous
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743092/
https://www.ncbi.nlm.nih.gov/pubmed/36442155
http://dx.doi.org/10.1021/acs.jmedchem.2c01469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743092/
https://www.ncbi.nlm.nih.gov/pubmed/36442155
http://dx.doi.org/10.1021/acs.jmedchem.2c01469

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