Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3′-Deoxyadenosine, as a Potential Anticancer Agent

[Image: see text] 3′-Deoxyadenosine (3′-dA, Cordycepin, 1) is a nucleoside analogue with anticancer properties, but its clinical development has been hampered due to its deactivation by adenosine deaminase (ADA) and poor cellular uptake due to low expression of the human equilibrative transporter (h...

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Detalles Bibliográficos
Autores principales: Serpi, Michaela, Ferrari, Valentina, McGuigan, Christopher, Ghazaly, Essam, Pepper, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743095/
https://www.ncbi.nlm.nih.gov/pubmed/36417756
http://dx.doi.org/10.1021/acs.jmedchem.2c01348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743095/
https://www.ncbi.nlm.nih.gov/pubmed/36417756
http://dx.doi.org/10.1021/acs.jmedchem.2c01348

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