Hospital and laboratory outcomes of patients with COVID-19 who received vitamin D supplementation: a systematic review and meta-analysis of randomized controlled trials
Coronavirus disease 2019 (COVID-19) has a wide-ranging spectrum of clinical symptoms, from asymptomatic/mild to severe. Recent research indicates that, among several factors, a low vitamin D level is a modifiable risk factor for COVID-19 patients. This study aims to evaluate the effect of vitamin D...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743115/ https://www.ncbi.nlm.nih.gov/pubmed/36508011 http://dx.doi.org/10.1007/s00210-022-02360-x |
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author | Zaazouee, Mohamed Sayed Eleisawy, Mahmoud Abdalalaziz, Amira M. Elhady, Mahmoud M. Ali, Omar Adel Abdelbari, Taghreed Mohamed Hasan, Sara Mohamed Almadhoon, Hossam Waleed Ahmed, Alaa Yehia Fassad, Alaa Shaban Elgendy, Rewan Abdel-Baset, Eman Adnan Elsayed, Hamis A. Elsnhory, Ahmed Bostamy Abdraboh, Alaa Bahaaeldin Faragalla, Hazem Metwally Elshanbary, Alaa Ahmed Kensara, Osama A. Abdel-Daim, Mohamed M. |
author_facet | Zaazouee, Mohamed Sayed Eleisawy, Mahmoud Abdalalaziz, Amira M. Elhady, Mahmoud M. Ali, Omar Adel Abdelbari, Taghreed Mohamed Hasan, Sara Mohamed Almadhoon, Hossam Waleed Ahmed, Alaa Yehia Fassad, Alaa Shaban Elgendy, Rewan Abdel-Baset, Eman Adnan Elsayed, Hamis A. Elsnhory, Ahmed Bostamy Abdraboh, Alaa Bahaaeldin Faragalla, Hazem Metwally Elshanbary, Alaa Ahmed Kensara, Osama A. Abdel-Daim, Mohamed M. |
author_sort | Zaazouee, Mohamed Sayed |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) has a wide-ranging spectrum of clinical symptoms, from asymptomatic/mild to severe. Recent research indicates that, among several factors, a low vitamin D level is a modifiable risk factor for COVID-19 patients. This study aims to evaluate the effect of vitamin D on hospital and laboratory outcomes of patients with COVID-19. Five databases (PubMed, Embase, Scopus, Web of Science, and Cochrane Library) and clinicaltrials.gov were searched until July 2022, using relevant keywords/Mesh terms. Only randomized clinical trials (RCTs) that addressed the topic were included. The Cochrane tool was used to assess the studies’ risk of bias, and the data were analyzed using the review manager (RevMan 5.4). We included nine RCTs with 1586 confirmed COVID-19 patients. Vitamin D group showed a significant reduction of intensive care unit (ICU) admission (risk ratio = 0.59, 95% confidence interval (CI) [0.41, 0.84], P = 0.003), and higher change in vitamin D level (standardized mean difference = 2.27, 95% CI [2.08, 2.47], P < 0.00001) compared to the control group. Other studied hospital and laboratory outcomes showed non-significant difference between vitamin D and the control group (P ≥ 0.05). In conclusion, vitamin D reduced the risk of ICU admission and showed superiority in changing vitamin D level compared to the control group. However, other outcomes showed no difference between the two groups. More RCTs are needed to confirm these results. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00210-022-02360-x. |
format | Online Article Text |
id | pubmed-9743115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-97431152022-12-13 Hospital and laboratory outcomes of patients with COVID-19 who received vitamin D supplementation: a systematic review and meta-analysis of randomized controlled trials Zaazouee, Mohamed Sayed Eleisawy, Mahmoud Abdalalaziz, Amira M. Elhady, Mahmoud M. Ali, Omar Adel Abdelbari, Taghreed Mohamed Hasan, Sara Mohamed Almadhoon, Hossam Waleed Ahmed, Alaa Yehia Fassad, Alaa Shaban Elgendy, Rewan Abdel-Baset, Eman Adnan Elsayed, Hamis A. Elsnhory, Ahmed Bostamy Abdraboh, Alaa Bahaaeldin Faragalla, Hazem Metwally Elshanbary, Alaa Ahmed Kensara, Osama A. Abdel-Daim, Mohamed M. Naunyn Schmiedebergs Arch Pharmacol Review Coronavirus disease 2019 (COVID-19) has a wide-ranging spectrum of clinical symptoms, from asymptomatic/mild to severe. Recent research indicates that, among several factors, a low vitamin D level is a modifiable risk factor for COVID-19 patients. This study aims to evaluate the effect of vitamin D on hospital and laboratory outcomes of patients with COVID-19. Five databases (PubMed, Embase, Scopus, Web of Science, and Cochrane Library) and clinicaltrials.gov were searched until July 2022, using relevant keywords/Mesh terms. Only randomized clinical trials (RCTs) that addressed the topic were included. The Cochrane tool was used to assess the studies’ risk of bias, and the data were analyzed using the review manager (RevMan 5.4). We included nine RCTs with 1586 confirmed COVID-19 patients. Vitamin D group showed a significant reduction of intensive care unit (ICU) admission (risk ratio = 0.59, 95% confidence interval (CI) [0.41, 0.84], P = 0.003), and higher change in vitamin D level (standardized mean difference = 2.27, 95% CI [2.08, 2.47], P < 0.00001) compared to the control group. Other studied hospital and laboratory outcomes showed non-significant difference between vitamin D and the control group (P ≥ 0.05). In conclusion, vitamin D reduced the risk of ICU admission and showed superiority in changing vitamin D level compared to the control group. However, other outcomes showed no difference between the two groups. More RCTs are needed to confirm these results. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00210-022-02360-x. Springer Berlin Heidelberg 2022-12-12 2023 /pmc/articles/PMC9743115/ /pubmed/36508011 http://dx.doi.org/10.1007/s00210-022-02360-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Zaazouee, Mohamed Sayed Eleisawy, Mahmoud Abdalalaziz, Amira M. Elhady, Mahmoud M. Ali, Omar Adel Abdelbari, Taghreed Mohamed Hasan, Sara Mohamed Almadhoon, Hossam Waleed Ahmed, Alaa Yehia Fassad, Alaa Shaban Elgendy, Rewan Abdel-Baset, Eman Adnan Elsayed, Hamis A. Elsnhory, Ahmed Bostamy Abdraboh, Alaa Bahaaeldin Faragalla, Hazem Metwally Elshanbary, Alaa Ahmed Kensara, Osama A. Abdel-Daim, Mohamed M. Hospital and laboratory outcomes of patients with COVID-19 who received vitamin D supplementation: a systematic review and meta-analysis of randomized controlled trials |
title | Hospital and laboratory outcomes of patients with COVID-19 who received vitamin D supplementation: a systematic review and meta-analysis of randomized controlled trials |
title_full | Hospital and laboratory outcomes of patients with COVID-19 who received vitamin D supplementation: a systematic review and meta-analysis of randomized controlled trials |
title_fullStr | Hospital and laboratory outcomes of patients with COVID-19 who received vitamin D supplementation: a systematic review and meta-analysis of randomized controlled trials |
title_full_unstemmed | Hospital and laboratory outcomes of patients with COVID-19 who received vitamin D supplementation: a systematic review and meta-analysis of randomized controlled trials |
title_short | Hospital and laboratory outcomes of patients with COVID-19 who received vitamin D supplementation: a systematic review and meta-analysis of randomized controlled trials |
title_sort | hospital and laboratory outcomes of patients with covid-19 who received vitamin d supplementation: a systematic review and meta-analysis of randomized controlled trials |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743115/ https://www.ncbi.nlm.nih.gov/pubmed/36508011 http://dx.doi.org/10.1007/s00210-022-02360-x |
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