Vector design for enhancing expression level and assembly of knob-into-hole based FabscFv-Fc bispecific antibodies in CHO cells

BACKGROUND: Two-armed FabscFv-Fc is a favoured bispecific antibody (BsAb) format due to its advantages of the conventional IgG structure. Production of FabscFv-Fc requires expression of three polypeptide chains, one light chain (LC), one heavy chain (HC) and a scFv fused to the Fc (scFvFc) at optima...

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Detalles Bibliográficos
Autores principales: Ong, Han Kee, Nguyen, Ngan T B, Bi, Jiawu, Yang, Yuansheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743168/
https://www.ncbi.nlm.nih.gov/pubmed/36518226
http://dx.doi.org/10.1093/abt/tbac025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743168/
https://www.ncbi.nlm.nih.gov/pubmed/36518226
http://dx.doi.org/10.1093/abt/tbac025

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