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Conformational Change of Transcription Factors from Search to Specific Binding: A lac Repressor Case Study

[Image: see text] In a process known as facilitated diffusion, DNA-binding proteins find their target sites by combining three-dimensional diffusion and one-dimensional scanning of the DNA. Following the trade-off between speed and stability, agile exploration of DNA requires loose binding, whereas,...

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Detalles Bibliográficos
Autores principales: Lüking, Malin, Elf, Johan, Levy, Yaakov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743208/
https://www.ncbi.nlm.nih.gov/pubmed/36416228
http://dx.doi.org/10.1021/acs.jpcb.2c05006