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Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs?

[Image: see text] With their three points of diversity, α-acyloxy carboxamides, which are accessible with the Passerini reaction, provide heterogeneity for the preparation of libraries of putative active agents or intermediates used for the formation of more complex structures. If on the one hand th...

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Detalles Bibliográficos
Autores principales: Brunelli, Francesca, Ceresa, Chiara, Fracchia, Letizia, Tron, Gian Cesare, Aprile, Silvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743426/
https://www.ncbi.nlm.nih.gov/pubmed/36518692
http://dx.doi.org/10.1021/acsmedchemlett.2c00420