Distance-dependent inhibition of translation initiation by downstream out-of-frame AUGs is consistent with a Brownian ratchet process of ribosome scanning

BACKGROUND: Eukaryotic ribosomes are widely presumed to scan mRNA for the AUG codon to initiate translation in a strictly 5′–3′ movement (i.e., strictly unidirectional scanning model), so that ribosomes initiate translation exclusively at the 5′ proximal AUG codon (i.e., the first-AUG rule). RESULTS...

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Detalles Bibliográficos
Autores principales: Li, Ke, Kong, Jinhui, Zhang, Shuo, Zhao, Tong, Qian, Wenfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743702/
https://www.ncbi.nlm.nih.gov/pubmed/36510274
http://dx.doi.org/10.1186/s13059-022-02829-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743702/
https://www.ncbi.nlm.nih.gov/pubmed/36510274
http://dx.doi.org/10.1186/s13059-022-02829-1

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