Treatment with quercetin inhibits SARS-CoV-2 N protein-induced acute kidney injury by blocking Smad3-dependent G1 cell-cycle arrest

Increasing evidence shows that SARS-CoV-2 can infect kidneys and cause acute kidney injury (AKI) in critically ill COVID-19 patients. However, mechanisms through which COVID-19 induces AKI are largely unknown, and treatment remains ineffective. Here, we report that kidney-specific overexpressing SAR...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Wenjing, Wang, Wenbiao, Liang, Liying, Chen, Junzhe, Wei, Biao, Huang, Xiao-Ru, Wang, Xiaoqin, Yu, Xueqing, Lan, Hui-Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743779/
https://www.ncbi.nlm.nih.gov/pubmed/36514292
http://dx.doi.org/10.1016/j.ymthe.2022.12.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743779/
https://www.ncbi.nlm.nih.gov/pubmed/36514292
http://dx.doi.org/10.1016/j.ymthe.2022.12.002

Ejemplares similares