Cargando…

Time-dependent alterations in the rat nigrostriatal system after intrastriatal injection of fibrils formed by α–Syn and tau fragments

INTRODUCTION: Accurate demonstration of phosphorylated α-synuclein aggregation and propagation, progressive nigrostriatal degeneration and motor deficits will help further research on elucidating the mechanisms of Parkinson’s Disease. α-synucleinN103 and tauN368, cleaved by activated asparagine endo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Xiaoman, Wang, Jialing, Zeng, Weiqi, Zhang, Xiaoqian, Yang, Xiaomei, Xu, Yu, Xu, Yan, Cao, Xuebing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744116/ https://www.ncbi.nlm.nih.gov/pubmed/36518823 http://dx.doi.org/10.3389/fnagi.2022.1049418

Ejemplares similares

Histological Correlates of Neuroanatomical Changes in a Rat Model of Levodopa-Induced Dyskinesia Based on Voxel-Based Morphometry
por: Zhang, Xiaoqian, et al.
Publicado: (2021)

Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease
por: Zeng, Weiqi, et al.
Publicado: (2022)

T Cells Limit Accumulation of Aggregate Pathology Following Intrastriatal Injection of α-Synuclein Fibrils
por: George, Sonia, et al.
Publicado: (2021)

The γ-Adducin 1–357 fragment promotes tau pathology
por: Yu, Honglu, et al.
Publicado: (2023)

A Combined α-Synuclein/Fibril (SynFib) Model of Parkinson-Like Synucleinopathy Targeting the Nigrostriatal Dopamine System
por: Björklund, Anders, et al.
Publicado: (2022)

The identities of insulin signaling pathway are affected by overexpression of Tau and its phosphorylation form
por: Ma, Ningtian, et al.
Publicado: (2022)

Analysis of hemisphere-dependent effects of unilateral intrastriatal injection of α-synuclein pre-formed fibrils on mitochondrial protein levels, dynamics, and function
por: Creed, Rose B., et al.
Publicado: (2022)

LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP
por: Tan, Yang, et al.
Publicado: (2020)

Plasma tau proteins for the diagnosis of mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis
por: Chen, Leian, et al.
Publicado: (2022)

Syntaxins 6 and 8 facilitate tau into secretory pathways
por: Lee, Wei Siang, et al.
Publicado: (2021)

Age-dependent accumulation of tau aggregation in Caenorhabditis elegans
por: Aquino Nunez, Wendy, et al.
Publicado: (2022)

Pathogenic tau decreases nuclear tension in cultured neurons
por: Sohn, Claira, et al.
Publicado: (2023)

Membrane interaction and disulphide-bridge formation in the unconventional secretion of Tau
por: Hellén, Marianna, et al.
Publicado: (2021)

Shapeshifting tau: from intrinsically disordered to paired-helical filaments
por: Mengham, Kurtis, et al.
Publicado: (2022)

Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice
por: Earls, Rachael H., et al.
Publicado: (2019)

Peripheral inflammation promotes brain tau transmission via disrupting blood–brain barrier
por: Liu, Yanchao, et al.
Publicado: (2020)

Kinetics and durability of transgene expression after intrastriatal injection of AAV9 vectors
por: Hollidge, Bradley S., et al.
Publicado: (2022)

Tau Pathology Profile Across a Parietal-Hippocampal Brain Network Is Associated With Spatial Reorientation Learning and Memory Performance in the 3xTg-AD Mouse
por: Stimmell, Alina C., et al.
Publicado: (2021)

Intrastriatal injection of Parkinson’s disease intestine and vagus lysates initiates α-synucleinopathy in rat brain
por: Yang, Zhaofei, et al.
Publicado: (2023)

Intrastriatal injections of KN-93 ameliorates levodopa-induced dyskinesia in a rat model of Parkinson’s disease
por: Yang, Xinxin, et al.
Publicado: (2013)

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity
por: Sorrentino, Zachary A., et al.
Publicado: (2017)

Antioxidant Effect of Alpha-Lipoic Acid in 6-Hydroxydopamine Unilateral Intrastriatal Injected Rats
por: Andreeva-Gateva, Pavlina, et al.
Publicado: (2020)

Tau kinetics in Alzheimer's disease
por: Hier, Daniel B., et al.
Publicado: (2022)

Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid
por: Saliba, Soraya Wilke, et al.
Publicado: (2017)

Pro-Inflammatory Role of AQP4 in Mice Subjected to Intrastriatal Injections of the Parkinsonogenic Toxin MPP+
por: Prydz, Agnete, et al.
Publicado: (2020)

Two vicious circles associated with the aging of the immune system in the development of severe forms of COVID-19
por: Vrbic, Miodrag, et al.
Publicado: (2023)

The Fate of Tau Aggregates Between Clearance and Transmission
por: Seitkazina, Assel, et al.
Publicado: (2022)

The prion-like transmission of tau oligomers via exosomes
por: Jackson, Noel A., et al.
Publicado: (2022)

Endolymphatic Hydrop Phenotype in Familial Norrie Disease Caused by Large Fragment Deletion of NDP
por: Gong, Yuerong, et al.
Publicado: (2022)

Repeated Intrastriatal Botulinum Neurotoxin-A Injection in Hemiparkinsonian Rats Increased the Beneficial Effect on Rotational Behavior
por: Hawlitschka, Alexander, et al.
Publicado: (2018)

The voiding efficiency in rat models with dopaminergic brain lesions induced through unilateral and bilateral intrastriatal injections
por: Praveen Rajneesh, Chellappan, et al.
Publicado: (2020)

Tau Acts in Concert With Kinase/Phosphatase Underlying Synaptic Dysfunction
por: Fan, Xing, et al.
Publicado: (2022)

Two simple assays for assessing the seeding activity of proteopathic tau
por: Liu, Fei, et al.
Publicado: (2023)

Subjective cognitive decline may mediate the occurrence of postoperative delirium by P-tau undergoing total hip replacement: The PNDABLE study
por: Liu, Fanghao, et al.
Publicado: (2022)

Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid‐induced biochemical alteration in mice
por: Liu, Peng, et al.
Publicado: (2019)

Fibril-Forming Motifs Are Essential and Sufficient for the Fibrillization of Human Tau
por: Meng, Sheng-Rong, et al.
Publicado: (2012)

Phosphorylated Tau 181 Serum Levels Predict Alzheimer’s Disease in the Preclinical Stage
por: Qin, Wei, et al.
Publicado: (2022)

Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse
por: Benskey, Matthew J., et al.
Publicado: (2023)

Experimental Intrastriatal Applications of Botulinum Neurotoxin-A: A Review
por: Hawlitschka, Alexander, et al.
Publicado: (2018)

Heart fatty acid-binding protein is associated with phosphorylated tau and longitudinal cognitive changes
por: Fu, Yan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fm2efhq2687r8a5bgglrfa5ps8