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Screening of high-risk deleterious missense variations in the CYP1B1 gene implicated in the pathogenesis of primary congenital glaucoma: A comprehensive in silico approach

BACKGROUND: Primary congenital glaucoma (PCG) is the most common subtype of glaucoma caused by defects in the cytochrome P450 1B1 (CYP1B1) gene. It is developing among infants in more than 80% of cases who exhibit impairments in the anterior chamber angle and the trabecular meshwork. Thus, a compreh...

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Detalles Bibliográficos
Autores principales:	Shahid, Muhammad, Azfaralariff, Ahmad, Tufail, Muhammad, Hussain Khan, Nazeer, Abdulkareem Najm, Ahmed, Firasat, Sabika, Zubair, Muhammad, Fazry, Shazrul, Law, Douglas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2022
Materias:	Bioinformatics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744154/ https://www.ncbi.nlm.nih.gov/pubmed/36518267 http://dx.doi.org/10.7717/peerj.14132

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