Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model

Background: Abnormal branched-chained amino acids (BCAA) accumulation in cardiomyocytes is associated with cardiac remodeling in heart failure. Administration of branched-chain α-keto acid dehydrogenase (BCKD) kinase inhibitor BT2 has been shown to reduce cardiac BCAA levels and demonstrated positiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Voronova, Veronika, Sokolov, Victor, Morias, Yannick, Boezelman, Malin Jonsson, Wågberg, Maria, Henricsson, Marcus, Hansson, Karl, Goltsov, Alexey, Peskov, Kirill, Sundqvist, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744226/
https://www.ncbi.nlm.nih.gov/pubmed/36518669
http://dx.doi.org/10.3389/fphar.2022.993422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744226/
https://www.ncbi.nlm.nih.gov/pubmed/36518669
http://dx.doi.org/10.3389/fphar.2022.993422

Ejemplares similares