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Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model

Background: Abnormal branched-chained amino acids (BCAA) accumulation in cardiomyocytes is associated with cardiac remodeling in heart failure. Administration of branched-chain α-keto acid dehydrogenase (BCKD) kinase inhibitor BT2 has been shown to reduce cardiac BCAA levels and demonstrated positiv...

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Detalles Bibliográficos
Autores principales:	Voronova, Veronika, Sokolov, Victor, Morias, Yannick, Boezelman, Malin Jonsson, Wågberg, Maria, Henricsson, Marcus, Hansson, Karl, Goltsov, Alexey, Peskov, Kirill, Sundqvist, Monika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744226/ https://www.ncbi.nlm.nih.gov/pubmed/36518669 http://dx.doi.org/10.3389/fphar.2022.993422

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