Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription

The exonuclease torpedo Xrn2 loads onto nascent RNA 5′-PO(4) ends and chases down pol II to promote termination downstream from polyA sites. We report that Xrn2 is recruited to preinitiation complexes and “travels” to 3′ ends of genes. Mapping of 5′-PO(4) ends in nascent RNA identified Xrn2 loading...

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Detalles Bibliográficos
Autores principales: Cortazar, Michael A., Erickson, Benjamin, Fong, Nova, Pradhan, Sarala J., Ntini, Evgenia, Bentley, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744234/
https://www.ncbi.nlm.nih.gov/pubmed/36396340
http://dx.doi.org/10.1101/gad.350004.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744234/
https://www.ncbi.nlm.nih.gov/pubmed/36396340
http://dx.doi.org/10.1101/gad.350004.122

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