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Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription
The exonuclease torpedo Xrn2 loads onto nascent RNA 5′-PO(4) ends and chases down pol II to promote termination downstream from polyA sites. We report that Xrn2 is recruited to preinitiation complexes and “travels” to 3′ ends of genes. Mapping of 5′-PO(4) ends in nascent RNA identified Xrn2 loading...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744234/ https://www.ncbi.nlm.nih.gov/pubmed/36396340 http://dx.doi.org/10.1101/gad.350004.122 |