Pterin-based small molecule inhibitor capable of binding to the secondary pocket in the active site of ricin-toxin A chain

The Ricin toxin A chain (RTA), which depurinates an adenine base at a specific region of the ribosome leading to death, has two adjacent specificity pockets in its active site. Based on this structural information, many attempts have been made to develop small-molecule RTA inhibitors that simultaneo...

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Detalles Bibliográficos
Autores principales: Saito, Ryota, Goto, Masaru, Katakura, Shun, Ohba, Taro, Kawata, Rena, Nagatsu, Kazuki, Higashi, Shoko, Kurisu, Kaede, Matsumoto, Kaori, Ohtsuka, Kouta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744275/
https://www.ncbi.nlm.nih.gov/pubmed/36508422
http://dx.doi.org/10.1371/journal.pone.0277770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744275/
https://www.ncbi.nlm.nih.gov/pubmed/36508422
http://dx.doi.org/10.1371/journal.pone.0277770

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