Cargando…
Pterin-based small molecule inhibitor capable of binding to the secondary pocket in the active site of ricin-toxin A chain
The Ricin toxin A chain (RTA), which depurinates an adenine base at a specific region of the ribosome leading to death, has two adjacent specificity pockets in its active site. Based on this structural information, many attempts have been made to develop small-molecule RTA inhibitors that simultaneo...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744275/ https://www.ncbi.nlm.nih.gov/pubmed/36508422 http://dx.doi.org/10.1371/journal.pone.0277770 |