Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood–brain barrier shuttle scFv8D3

The blood–brain barrier (BBB) greatly limits the delivery of protein-based drugs into the brain and is a major obstacle for the treatment of brain disorders. Targeting the transferrin receptor (TfR) is a strategy for transporting protein-based drugs into the brain, which can be utilized by using TfR...

Descripción completa

Detalles Bibliográficos
Autores principales: de la Rosa, Andrés, Metzendorf, Nicole G., Morrison, Jamie I., Faresjö, Rebecca, Rofo, Fadi, Petrovic, Alex, O’Callaghan, Paul, Syvänen, Stina, Hultqvist, Greta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744743/
https://www.ncbi.nlm.nih.gov/pubmed/36509864
http://dx.doi.org/10.1038/s41598-022-25965-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744743/
https://www.ncbi.nlm.nih.gov/pubmed/36509864
http://dx.doi.org/10.1038/s41598-022-25965-x

Ejemplares similares