Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer

The brain is a major sanctuary site for metastatic cancer cells that evade systemic therapies. Through pre-clinical pharmacological, biological, and molecular studies, we characterize the functional link between drug resistance and central nervous system (CNS) relapse in Epidermal Growth Factor Rece...

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Detalles Bibliográficos
Autores principales: Adua, Sally J., Arnal-Estapé, Anna, Zhao, Minghui, Qi, Bowen, Liu, Zongzhi Z., Kravitz, Carolyn, Hulme, Heather, Strittmatter, Nicole, López-Giráldez, Francesc, Chande, Sampada, Albert, Alexandra E., Melnick, Mary-Ann, Hu, Bomiao, Politi, Katerina, Chiang, Veronica, Colclough, Nicola, Goodwin, Richard J. A., Cross, Darren, Smith, Paul, Nguyen, Don X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744876/
https://www.ncbi.nlm.nih.gov/pubmed/36509758
http://dx.doi.org/10.1038/s41467-022-34889-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744876/
https://www.ncbi.nlm.nih.gov/pubmed/36509758
http://dx.doi.org/10.1038/s41467-022-34889-z

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