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Use of Leishmania major parasites expressing a recombinant Trypanosoma cruzi antigen as live vaccines against Chagas disease

INTRODUCTION: Trypanosoma cruzi is the protozoan parasite causing Chagas disease, a Neglected Tropical Disease that affects 8 million people and causes 12,000 deaths per year, primarily because of cardiac pathology. Effective vaccination for T. cruzi remains an elusive goal. The use of a live vaccin...

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Detalles Bibliográficos
Autores principales: Cai, Catherine W., O’Shea, Anne, Eickhoff, Christopher S., Guo, Hongjie, Lewis, Warren G., Beverley, Stephen M., Hoft, Daniel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745109/
https://www.ncbi.nlm.nih.gov/pubmed/36523834
http://dx.doi.org/10.3389/fmicb.2022.1059115