Structure-based discovery of a novel small-molecule inhibitor of TEAD palmitoylation with anticancer activity

The paralogous oncogenic transcriptional coactivators YAP and TAZ are the distal effectors of the Hippo signaling pathway, which plays a critical role in cell proliferation, survival and cell fate specification. They are frequently deregulated in most human cancers, where they contribute to multiple...

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Detalles Bibliográficos
Autores principales: Gridnev, Artem, Maity, Subhajit, Misra, Jyoti R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745137/
https://www.ncbi.nlm.nih.gov/pubmed/36523977
http://dx.doi.org/10.3389/fonc.2022.1021823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745137/
https://www.ncbi.nlm.nih.gov/pubmed/36523977
http://dx.doi.org/10.3389/fonc.2022.1021823

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