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Structure-based discovery of a novel small-molecule inhibitor of TEAD palmitoylation with anticancer activity
The paralogous oncogenic transcriptional coactivators YAP and TAZ are the distal effectors of the Hippo signaling pathway, which plays a critical role in cell proliferation, survival and cell fate specification. They are frequently deregulated in most human cancers, where they contribute to multiple...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745137/ https://www.ncbi.nlm.nih.gov/pubmed/36523977 http://dx.doi.org/10.3389/fonc.2022.1021823 |