Geranylgeranyl pyrophosphate depletion by statins compromises skeletal muscle insulin sensitivity

BACKGROUND: Statins are widely prescribed cholesterol‐lowering drugs but have been shown to increase the risk of type 2 diabetes mellitus. However, the molecular mechanisms underlying the diabetogenic effect of statins are still not fully understood. METHODS: The effects of geranylgeranyl transferas...

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Detalles Bibliográficos
Autores principales: Wang, Lai, Zheng, Zuguo, Zhu, Lijun, Meng, Lingchang, Liu, Hanling, Wang, Keke, Chen, Jun, Li, Ping, Yang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745480/
https://www.ncbi.nlm.nih.gov/pubmed/35961942
http://dx.doi.org/10.1002/jcsm.13061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745480/
https://www.ncbi.nlm.nih.gov/pubmed/35961942
http://dx.doi.org/10.1002/jcsm.13061

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