Insights into the Spectrum of Activity and Mechanism of Action of MGB-BP-3

[Image: see text] MGB-BP-3 is a potential first-in-class antibiotic, a Strathclyde Minor Groove Binder (S-MGB), that has successfully completed Phase IIa clinical trials for the treatment of Clostridioides difficile associated disease. Its precise mechanism of action and the origin of limited activi...

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Detalles Bibliográficos
Autores principales: Hind, Charlotte, Clifford, Melanie, Woolley, Charlotte, Harmer, Jane, McGee, Leah M. C., Tyson-Hirst, Izaak, Tait, Henry J., Brooke, Daniel P., Dancer, Stephanie J., Hunter, Iain S., Suckling, Colin J., Beveridge, Rebecca, Parkinson, John A., Sutton, J. Mark, Scott, Fraser J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745797/
https://www.ncbi.nlm.nih.gov/pubmed/36444998
http://dx.doi.org/10.1021/acsinfecdis.2c00445

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