Polycomb EZH1 regulates cell cycle/5‐fluorouracil sensitivity of neuroblastoma cells in concert with MYCN

In the present study, we found that EZH1 depletion in MYCN‐amplified neuroblastoma cells resulted in significant cell death as well as xenograft inhibition. EZH1 depletion decreased the level of H3K27me1; the interaction and protein stabilization of MYCN and EZH1 appear to play roles in epigenetic t...

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Detalles Bibliográficos
Autores principales: Shinno, Yoshitaka, Takenobu, Hisanori, Sugino, Ryuichi P., Endo, Yuki, Okada, Ryu, Haruta, Masayuki, Satoh, Shunpei, Mukae, Kyosuke, Shaliman, Dilibaerguli, Wada, Tomoko, Akter, Jesmin, Ando, Kiyohiro, Nakazawa, Atsuko, Yoshida, Hideo, Ohira, Miki, Hishiki, Tomoro, Kamijo, Takehiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746046/
https://www.ncbi.nlm.nih.gov/pubmed/36052716
http://dx.doi.org/10.1111/cas.15555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746046/
https://www.ncbi.nlm.nih.gov/pubmed/36052716
http://dx.doi.org/10.1111/cas.15555

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