Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes

BACKGROUND: Human proteins are widely used as drug targets. Integration of large-scale protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus connected genetic variation to disease mechanisms via protein. Previous proteome-by-phenome-wide Mendelian randomization (MR)...

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Detalles Bibliográficos
Autores principales: Yang, Chengran, Fagan, Anne M., Perrin, Richard J., Rhinn, Herve, Harari, Oscar, Cruchaga, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746220/
https://www.ncbi.nlm.nih.gov/pubmed/36510323
http://dx.doi.org/10.1186/s13073-022-01140-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746220/
https://www.ncbi.nlm.nih.gov/pubmed/36510323
http://dx.doi.org/10.1186/s13073-022-01140-9

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