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Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes

BACKGROUND: Human proteins are widely used as drug targets. Integration of large-scale protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus connected genetic variation to disease mechanisms via protein. Previous proteome-by-phenome-wide Mendelian randomization (MR)...

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Detalles Bibliográficos
Autores principales:	Yang, Chengran, Fagan, Anne M., Perrin, Richard J., Rhinn, Herve, Harari, Oscar, Cruchaga, Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746220/ https://www.ncbi.nlm.nih.gov/pubmed/36510323 http://dx.doi.org/10.1186/s13073-022-01140-9

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