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mTOR–neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain

Neuropathic pain is a refractory condition that involves de novo protein synthesis in the nociceptive pathway. The mTOR is a master regulator of protein translation; however, mechanisms underlying its role in neuropathic pain remain elusive. Using the spared nerve injury–induced neuropathic pain mod...

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Detalles Bibliográficos
Autores principales: Chen, Lunhao, Hu, Yaling, Wang, Siyuan, Cao, Kelei, Mai, Weihao, Sha, Weilin, Ma, Huan, Zeng, Ling-Hui, Xu, Zhen-Zhong, Gao, Yong-Jing, Duan, Shumin, Wang, Yue, Gao, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746821/
https://www.ncbi.nlm.nih.gov/pubmed/36194480
http://dx.doi.org/10.1172/jci.insight.159247