Cargando…

mTOR–neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain

Neuropathic pain is a refractory condition that involves de novo protein synthesis in the nociceptive pathway. The mTOR is a master regulator of protein translation; however, mechanisms underlying its role in neuropathic pain remain elusive. Using the spared nerve injury–induced neuropathic pain mod...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Lunhao, Hu, Yaling, Wang, Siyuan, Cao, Kelei, Mai, Weihao, Sha, Weilin, Ma, Huan, Zeng, Ling-Hui, Xu, Zhen-Zhong, Gao, Yong-Jing, Duan, Shumin, Wang, Yue, Gao, Zhihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746821/ https://www.ncbi.nlm.nih.gov/pubmed/36194480 http://dx.doi.org/10.1172/jci.insight.159247

Ejemplares similares

Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain
por: Zhao, Jing, et al.
Publicado: (2010)

Sensitized vasoactive C-nociceptors: key fibers in peripheral neuropathic pain
por: Forstenpointner, Julia, et al.
Publicado: (2019)

Local hyperexcitability of C-nociceptors may predict responsiveness to topical lidocaine in neuropathic pain
por: Landmann, Gunther, et al.
Publicado: (2022)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

mTOR regulates GPVI-mediated platelet activation
por: Wang, Longsheng, et al.
Publicado: (2021)

Pain-Relieving Effects of mTOR Inhibitor in the Anterior Cingulate Cortex of Neuropathic Rats
por: Um, Sun Woo, et al.
Publicado: (2018)

Control of mTOR Signaling by Ubiquitin
por: Jiang, Yao, et al.
Publicado: (2019)

Blocking mammalian target of rapamycin (mTOR) improves neuropathic pain evoked by spinal cord injury
por: Wang, Xiaoping, et al.
Publicado: (2016)

Experimental Approaches in Delineating mTOR Signaling
por: Qian, Jiayi, et al.
Publicado: (2020)

Characterization of two Runx1-dependent nociceptor differentiation programs necessary for inflammatory versus neuropathic pain
por: Samad, Omar Abdel, et al.
Publicado: (2010)

Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain
por: Berta, Temugin, et al.
Publicado: (2017)

Gambogic acid affects ESCC progression through regulation of PI3K/AKT/mTOR signal pathway
por: Yu, Jiarui, et al.
Publicado: (2020)

STAT3 and mTOR: co-operating to drive HIF and angiogenesis
por: Dodd, Kayleigh M., et al.
Publicado: (2015)

mTOR Complexes as a Nutrient Sensor for Driving Cancer Progression
por: Harachi, Mio, et al.
Publicado: (2018)

mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging
por: Van Skike, Candice E., et al.
Publicado: (2019)

Combined therapy of prednisone and mTOR inhibitor sirolimus for treating retroperitoneal fibrosis
por: Gao, Hui, et al.
Publicado: (2023)

Inhibition of visceral nociceptors
por: Reed, David E., et al.
Publicado: (2014)

Defining the nociceptor transcriptome
por: Thakur, Matthew, et al.
Publicado: (2014)

Epac and nociceptor sensitization
por: Huang, Li-Yen M, et al.
Publicado: (2017)

Hyperbaric oxygen relieves neuropathic pain through AKT/TSC2/mTOR pathway activity to induce autophagy
por: Liu, Yong-Da, et al.
Publicado: (2019)

Control of myeloid cell functions by nociceptors
por: Hanč, Pavel, et al.
Publicado: (2023)

Identification of a Receptor for Neuropeptide VGF and Its Role in Neuropathic Pain
por: Chen, Ya-Chun, et al.
Publicado: (2013)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

Nociceptors: a phylogenetic view
por: Smith, Ewan St. John, et al.
Publicado: (2009)

Chloride – The Underrated Ion in Nociceptors
por: Wilke, Bettina U., et al.
Publicado: (2020)

Molecular taxonomy of nociceptors and pruriceptors
por: Kupari, Jussi, et al.
Publicado: (2023)

Moderate-intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2X7/AMPK/mTOR axis
por: Li, Zihao, et al.
Publicado: (2021)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

PI3K/AKT/mTOR Signaling-Mediated Neuropeptide VGF in the Hippocampus of Mice Is Involved in the Rapid Onset Antidepressant-Like Effects of GLYX-13
por: Lu, Yang, et al.
Publicado: (2015)

The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease
por: Song, Yongli, et al.
Publicado: (2020)

Notch3-Mediated mTOR Signaling Pathway Is Involved in High Glucose-Induced Autophagy in Bovine Kidney Epithelial Cells
por: Cui, Yaocheng, et al.
Publicado: (2022)

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
por: Zheng, Xiangjin, et al.
Publicado: (2021)

MiR-1906 Attenuates Neuropathic Pain in Rats by Regulating the TLR4/mTOR/ Akt Signaling Pathway
por: Fang, Xianhai, et al.
Publicado: (2019)

Implication of microglia activation and CSF1/CSF1R pathway in lumbar disc degeneration-related back pain
por: Yang, Ge, et al.
Publicado: (2018)

HMGB1 released from nociceptors mediates inflammation
por: Yang, Huan, et al.
Publicado: (2021)

mTOR inhibitors in cancer therapy
por: Xie, Jianling, et al.
Publicado: (2016)

Effect and mechanism of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain and spinal microglia in a rat model of chronic constriction injury
por: Guo, Jian-Rong, et al.
Publicado: (2017)

Two kinesins drive anterograde neuropeptide transport
por: Lim, Angeline, et al.
Publicado: (2017)

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
por: Tian, Tian, et al.
Publicado: (2019)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ps92pbm7quo706qqhnuja4sj85