Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains

Sinoatrial node (SAN) cells are the heart’s primary pacemaker. Their activity is tightly regulated by β-adrenergic receptor (β-AR) signaling. Adenylyl cyclase (AC) is a key enzyme in the β-AR pathway that catalyzes the production of cAMP. There are current gaps in our knowledge regarding the dominan...

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Detalles Bibliográficos
Autores principales: Ren, Lu, Thai, Phung N., Gopireddy, Raghavender Reddy, Timofeyev, Valeriy, Ledford, Hannah A., Woltz, Ryan L., Park, Seojin, Puglisi, Jose L., Moreno, Claudia M., Santana, Luis Fernando, Conti, Alana C., Kotlikoff, Michael I., Xiang, Yang Kevin, Yarov-Yarovoy, Vladimir, Zaccolo, Manuela, Zhang, Xiao-Dong, Yamoah, Ebenezer N., Navedo, Manuel F., Chiamvimonvat, Nipavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746826/
https://www.ncbi.nlm.nih.gov/pubmed/36509290
http://dx.doi.org/10.1172/jci.insight.162602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746826/
https://www.ncbi.nlm.nih.gov/pubmed/36509290
http://dx.doi.org/10.1172/jci.insight.162602

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