Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer

The aberrant activation of STAT3 is associated with the etiology and progression in a variety of malignant epithelial-derived tumors, including head and neck squamous cell carcinoma (HNSCC) and colorectal cancer (CRC). Due to the lack of an enzymatic catalytic site or a ligand-binding pocket, there...

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Detalles Bibliográficos
Autores principales: Jin, Jinmei, Wu, Yaping, Zhao, Zeng, Wu, Ye, Zhou, Yu-dong, Liu, Sanhong, Sun, Qingyan, Yang, Guizhu, Lin, Jiayi, Nagle, Dale G., Qin, Jiangjiang, Zhang, Zhiyuan, Chen, Hong-zhuan, Zhang, Weidong, Sun, Shuyang, Luan, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746828/
https://www.ncbi.nlm.nih.gov/pubmed/36509291
http://dx.doi.org/10.1172/jci.insight.160606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746828/
https://www.ncbi.nlm.nih.gov/pubmed/36509291
http://dx.doi.org/10.1172/jci.insight.160606

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