Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling

High endothelial venule protein/SPARC-like 1 (hevin/Sparcl1) is an astrocyte-secreted protein that regulates synapse formation in the brain. Here we show that astrocytic hevin signaling plays a critical role in maintaining chronic pain. Compared with WT mice, hevin-null mice exhibited normal mechani...

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Detalles Bibliográficos
Autores principales: Chen, Gang, Xu, Jing, Luo, Hao, Luo, Xin, Singh, Sandeep K., Ramirez, Juan J., James, Michael L., Mathew, Joseph P., Berger, Miles, Eroglu, Cagla, Ji, Ru-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746899/
https://www.ncbi.nlm.nih.gov/pubmed/36256481
http://dx.doi.org/10.1172/jci.insight.161028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746899/
https://www.ncbi.nlm.nih.gov/pubmed/36256481
http://dx.doi.org/10.1172/jci.insight.161028

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